Research i_need_contribute
Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke
source:NCBI 2020-12-03 [Research]
Xin-Tong Su, 1 Lu Wang, 1 Si-Ming Ma, 2 Yan Cao, 1 Na-Na Yang, 2 Lu-Lu Lin, 1 Marc Fisher, 3 Jing-Wen Yang,corresponding author 1 and Cun-Zhi Liu 1 1Acupuncture Research Center, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China 2Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China 3Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA corresponding authorCorresponding author. Jing-Wen Yang: moc.621@6260wjgnay Guest Editor: Yue Liu

Abstract

Ischemic stroke is the major type of cerebrovascular disease usually resulting in death or disability among the aging population globally. Oxidative stress has been closely linked with ischemic stroke. Disequilibrium between excessive production of reactive oxygen species (ROS) and inherent antioxidant capacity leads to subsequent oxidative damage in the pathological progression of ischemic brain injury. Acupuncture has been applied widely in treating cerebrovascular diseases from time immemorial in China. This review mainly lays stress on the evidence to illuminate the possible mechanisms of acupuncture therapy in treating ischemic stroke through regulating oxidative stress. We found that by regulating a battery of molecular signaling pathways involved in redox modulation, acupuncture not only activates the inherent antioxidant enzyme system but also inhibits the excessive generation of ROS. Acupuncture therapy possesses the potential in alleviating oxidative stress caused by cerebral ischemia, which may be linked with the neuroprotective effect of acupuncture.